Dynamics of Long-Term Quality of Life After Treatment for Esophageal Cancer: A Community-Based Patient Study

Dynamics of Long-Term Quality of Life After Treatment for Esophageal Cancer: A Community-Based Patient Study

Blog Article

PURPOSETo characterize the pattern of post-treatment quality of life (QoL) for esophageal cancer (EC) survivors and construct models predicting their long-term QoL.METHODSOn the basis of a randomized trial in an EC high-risk region in China, we interviewed 363 EC survivors and 25,245 permanent COMPLETE COLLAGEN UNFLAVOURED residents matched with the survivors on age, sex, and township as the baseline.QoL was measured using three-level version of European Quality of Life 5-Dimensions instrument.We constructed piecewise mixed models estimating the QoL of EC survivors that varied by age, sex, patient type, hospital level, and therapy to ascertain QoL determinants.RESULTSThe post-treatment QoL of EC survivors dropped by 15.

7% within the first year and recovered by 9.3% between 1 and 9 years compared with the baseline.Therapy was found to be a determinant of QoL, and a series of therapy-specific models were fitted accordingly, which all showed the pattern of decreasing rapidly and recovering gradually.Endoscopic treatment had the least impact on post-treatment QoL (7.5% drop within 5 years) compared with esophagectomy (12.

2% drop within 1 year) and chemoradiotherapy (37.8% drop within 2 years).The usual activities dimension showed the greatest impairment among those patients (34.4% drop within 1 year).CONCLUSIONThis community-based study described the long-term QoL trajectory for EC survivors after different therapeutic modalities and constructed models to predict therapy-specific QoL at different time points after treatment.

It provided new BURGUNDY CREME insights into decision making in treatment for EC from the perspective of QoL protection, offering a convenient tool for estimating quality-adjusted life-years.